AFS is a three-letter acronym that may refer to:

AFS Flexible Co., an HVAC equipments and flexible ducts factory

AFS Intercultural Programs, a student exchange program (formerly American Field Service)

Abington Friends School, in Jenkintown, Pennsylvania, United States

Advanced Forward-lighting System or Advanced Front-lighting System

Advanced Financial Solutions

Advanced Field Services, a division of Eagleeye Analytics, a U.S. company that provides advanced software and quality assurance solutions to insurance companies

Air Force Station, a type of facility maintained by the United States Air Force

Alliance for Security, an American political organization founded in 2004

American Folklore Society, the scholarly association of all folklorists in the United States

Andrew File System, a distributed networked file system

OpenAFS, an open source implementation of the Andrew File System

Anonymous File Sharing service that runs on GNUnet

Anti-funnel System, a Newtype technology in the manga Mobile Suit Gundam REON

Aquatic Fitness System, an aquatic swimming device

Armor for Sleep, an American rock band

Army Fire Service, the British Army's fire service

Ashford (Surrey) railway station (also know as the Ashford (Middlesex) station), United Kingdom according to the National Rail code

Association of Football Statisticians, a British football (soccer) statistical organisation

AtheOS File System, part of the Syllable operating system

Atomic Fluorescence Spectroscopy, a popular version of spectroscopy in the range of UV-light.

Automatic Frequency Switch, a system that is comparable with RDS function for radio. Invented by Alex de Jong from his company www.senergy.tw

Auxiliary Fire Service, a United Kingdom organization extant during the periods of 1938-1942 and 1948-1968

Combat stores ship, according to the United States Navy hull classification system

The ICAO Code for Air Data Limited, United Kingdom